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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha : |
21/02/2014 |
Actualizado : |
04/09/2018 |
Tipo de producción científica : |
Documentos |
Autor : |
DE BARBIERI, I.; MONTOSSI, F.; SILVEIRA, C.; LUZARDO, S.; SANCRISTOBAL, E.; ROVIRA, F.; BENTANCURT, M.; FRUGONI, J.; LEVRATTO, J.; CACERES, J.; BOTTERO, S.; CUADRO, P.; ALBERNÁZ, F. |
Afiliación : |
LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FABIO MARCELO MONTOSSI PORCHILE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINA INES SILVEIRA ROJAS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SANTIAGO FELIPE LUZARDO VILLAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS EMILIO SANCRISTOBAL RODRIGUEZ SOTTO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FERNANDO ROVIRA GALARRAGA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MAURO ANDRES BENTANCURT PONTTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JULIO CESAR FRUGONI SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN CARLOS LEVRATTO CORTES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN IGNACIO CACERES OLIVERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SERGIO DANIEL BOTTERO REGGI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Alimentación estratégia de ovejas Merino Australiano melliceras en el período esquila preparto temprana-parición para la mejora de la productividad ovina en la región de basalto. |
Fecha de publicación : |
2008 |
Fuente / Imprenta : |
ln: INIA Tacuarembó. Unidad Experimental Glencoe. Alternativas de intensificación, especialización, diversificación y valorización de la ganadería ovina y bovina en basalto. Tacuarembó (Uruguay): INIA, 2008. |
Páginas : |
p. 25-27 |
Idioma : |
Español |
Thesagro : |
BASALTO; GANADERIA; OVEJA. |
Asunto categoría : |
-- |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/4380/1/GLENCOE-2008SetGuia-de-actividad-Visita-guiada.pdf
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Marc : |
LEADER 01028nam a2200289 a 4500 001 1021630 005 2018-09-04 008 2008 bl uuuu u0uu1 u #d 100 1 $aDE BARBIERI, I. 245 $aAlimentación estratégia de ovejas Merino Australiano melliceras en el período esquila preparto temprana-parición para la mejora de la productividad ovina en la región de basalto. 260 $aln: INIA Tacuarembó. Unidad Experimental Glencoe. Alternativas de intensificación, especialización, diversificación y valorización de la ganadería ovina y bovina en basalto. Tacuarembó (Uruguay): INIA$c2008 300 $ap. 25-27 650 $aBASALTO 650 $aGANADERIA 650 $aOVEJA 700 1 $aMONTOSSI, F. 700 1 $aSILVEIRA, C. 700 1 $aLUZARDO, S. 700 1 $aSANCRISTOBAL, E. 700 1 $aROVIRA, F. 700 1 $aBENTANCURT, M. 700 1 $aFRUGONI, J. 700 1 $aLEVRATTO, J. 700 1 $aCACERES, J. 700 1 $aBOTTERO, S. 700 1 $aCUADRO, P. 700 1 $aALBERNÁZ, F.
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INIA Tacuarembó (TBO) |
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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
05/12/2016 |
Actualizado : |
09/10/2019 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
VERDES, J. M.; MÁRQUEZ, M.; CALLIARI, A.; BATES, D.; MORAÑA, J. A.; GIMENO, E. J.; ODRIOZOLA, E.; GIANNITTI, F.; GUERRERO, F.; FIDALGO, L. E.; PUMAROLA, M. |
Afiliación : |
JOSÉ MANUEL VERDES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); MERCEDES MÁRQUEZ, Universidad de Santiago de Compostela (USC); ALDO CALLIARI, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); DANIEL BATES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; JOSÉ ANTONIO MORAÑA, Universidad de la República (UdelaR)/ Facultad de Veterinaria; EDUARDO JUAN GIMENO, Universidad Nacional de la Plata (UNLP); ERNESTO ODRIOZOLA, INTA (Instituto Nacional de Tecnología Agropecuaria)- Balcarce; FEDERICO GIANNITTI, University of Minnesota, Saint Paul, MN, USA; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FLORENTINA GUERRERO, Universidad de Santiago de Compostela (USC); LUIS EUSEBIO FIDALGO, Universidad de Santiago de Compostela (USC); MARTÍ PUMAROLA, Universitat Autònoma de Barcelona. |
Título : |
A novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report) |
Fecha de publicación : |
2015 |
Fuente / Imprenta : |
Journal of Veterinary Diagnostic Investigation, 2015, v.27 (3): 278-286. |
DOI : |
10.1177/1040638715582048 |
Idioma : |
Inglés |
Notas : |
Article history: First Published April 21, 2015. |
Contenido : |
ABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death.
© 2015 The Author(s). MenosABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on th... Presentar Todo |
Palabras claves : |
BOVINE; CEREBELLAR DEGENERATION; CYTOSKELETAL DYSFUNCTION; PURKINJE CELLS; SOLANUM BONARIENSE. |
Thesagro : |
BOVINOS. |
Asunto categoría : |
L01 Ganadería |
Marc : |
LEADER 02961naa a2200337 a 4500 001 1056202 005 2019-10-09 008 2015 bl uuuu u00u1 u #d 024 7 $a10.1177/1040638715582048$2DOI 100 1 $aVERDES, J. M. 245 $aA novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report)$h[electronic resource] 260 $c2015 500 $aArticle history: First Published April 21, 2015. 520 $aABSTRACT. Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death. © 2015 The Author(s). 650 $aBOVINOS 653 $aBOVINE 653 $aCEREBELLAR DEGENERATION 653 $aCYTOSKELETAL DYSFUNCTION 653 $aPURKINJE CELLS 653 $aSOLANUM BONARIENSE 700 1 $aMÁRQUEZ, M. 700 1 $aCALLIARI, A. 700 1 $aBATES, D. 700 1 $aMORAÑA, J. A. 700 1 $aGIMENO, E. J. 700 1 $aODRIOZOLA, E. 700 1 $aGIANNITTI, F. 700 1 $aGUERRERO, F. 700 1 $aFIDALGO, L. E. 700 1 $aPUMAROLA, M. 773 $tJournal of Veterinary Diagnostic Investigation, 2015$gv.27 (3): 278-286.
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